Inhibition of Bovine Phenol Sulfotransferase (bSULT1A1) by CoA Thioesters EVIDENCE FOR POSITIVE COOPERATIVITY AND INHIBITION BY INTERACTION WITH BOTH THE NUCLEOTIDE AND PHENOL BINDING
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چکیده
*This work was supported by a grant from the National Science Foundation. The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact. **To whom correspondence should be addressed: Department of Biochemistry, Alma College, 614 W. Superior Street, Alma, MI 48801. Tel: 989-463-7208; Fax: 989-463-7076; E-mail: [email protected]
منابع مشابه
Inhibition of bovine phenol sulfotransferase (bSULT1A1) by CoA thioesters. Evidence for positive cooperativity and inhibition by interaction with both the nucleotide and phenol binding sites.
Previous work with the bovine phenol sulfotransferase (bSULT1A1, EC ) demonstrated inhibition by CoA that was competitive with respect to the sulfuryl donor substrate, 3'-phosphoadenosine-5'-phosphosulfate (PAPS) (Leach, M., Cameron, E., Fite, N., Stassinopoulos, J., Palmreuter, N., and Beckmann, J. D. (1999) Biochem. Biophys. Res. Commun. 261, 815-819). Here we report that long chain acyl-CoAs...
متن کاملInhibition of Bovine Phenol Sulfotransferase (bSULT1A1) by CoA Thioesters EVIDENCE FOR POSITIVE COOPERATIVITY AND INHIBITION BY INTERACTION WITH BOTH THE NUCLEOTIDE AND PHENOL BINDING SITES* (Running title: Palmitoyl-CoA Inhibits Phenol Sulfotransferase )
*This work was supported by a grant from the National Science Foundation. The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact. **To whom correspondence should be addressed: Department of Biochemistry, Alma College, 614 W. ...
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